The fatigue is the combination of glycogen depletion and your body failing to take up lactic acid.
I'd like to do the full Iron Man some day, which ends with a full marathon, but it take 30+ hours a week for about a year to prepare properly and my wife is not too keen on me taking long ocean swims, so probably just a fantasy.
Might get into spring tris and bis though. More well suited to my body type anyway. I'm way too stocky/heavy and a little short legged to be even remotely competitive at the long stuff. Those guys are freaks.
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